Our Work

mRNA export factors store nascent transcripts within nuclear speckles as an adaptive response to transient global inhibition of transcription

Molecular Cell, 85(1), 117–131 (2025)

TD Williams*, EM Michalak, KT Carey, EYN Lam …. JA Chao*, VO Wickramasinghe* and MA Dawson*

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Nuclear export of circular RNA

Nature, 627, 212–220 (2024)

LH Ngo, AG Bert, BK Dredge, T Williams, W Li, KT Carey … JA Chao, GJ Goodall* and VO Wickramasinghe*

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Adaptive translational reprogramming of metabolism limits the response to targeted therapy in BRAF V600 melanoma

Nature Communications, 13(1):1100 (2022)

LK Smith, T Parmenter ….  VO Wickramasinghe, RB Pearson and GA McArthur 

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Pathogenic variants in nucleoporin TPR cause severe intellectual disability in humans

Human Molecular Genetics, 31(3):362-375 (2022)

NJ Van Bergen, KM Bell, K Carey.... VO Wickramasinghe*, SM White* and J Christodoulou*

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RNA in cancer

Nature Reviews Cancer. 21(1):22-36 (2021) - Cover Image

GJ Goodall* and VO Wickramasinghe*

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Germline heterozygous mutations in Nxf1 perturb RNA metabolism and trigger thrombocytopenia and lymphopenia in mice

Blood Advances, 4 (7): 1270-1283. (2020)

S Chappaz, CW Law, MR Dowling, KT Carey, RM Lane, LH Ngo, VO Wickramasinghe, GK Smyth, ME Ritchie, BT Kile.

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A systems view of spliceosomal assembly and branchpoints with iCLIP

Nature Structural Molecular Biology 26(10):930-940 (2019)

M Briese, N Haberman, CR Sibley, R Faraway, AS Elser, AM Chakrabarti, Z Wang, J Konig, D Perera, VO Wickramasinghe, AR Venkitaraman, NM Luscombe, L Saieva, L Pellizzoni, CWJ Smith, T Curk and J Ule.

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Regulatory potential of the RNA processing machinery: Implications for human disease

Trends in Genetics 34 (4): 279-290. (2018)

KT Carey and VO Wickramasinghe*

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Nuclear export of RNA: Different sizes, shapes and functions

Seminars in Cell and Developmental Biology (17) 30059-9 (2017)

T Williams, LH Ngo and VO Wickramasinghe*

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Impact of alternative splicing on the human proteome

Cell Reports 20: 1229-1241 (2017) Research Highlight at Nature Methods

Y Liu, M Gonzàlez-Porta, S Santos, A Brazma, JC Marioni, R Aebersold*, AR Venkitaraman* and VO Wickramasinghe*

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RNA processing and genome stability: cause and consequence.

Molecular Cell 61 (4): 496-505. (2016)

VO Wickramasinghe* and AR Venkitaraman*

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Control of mammalian gene expression by selective mRNA export

Nature Reviews Molecular Cell Biology, 16 (7): 431-42 (2015)

VO Wickramasinghe* and RA Laskey*

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